Moraitis AA, Shreeve N, Sovio U, et al. - In this study, the diagnostic effectiveness of universal ultrasonic fetal biometry in predicting the delivery of a macrosomic infant, shoulder dystocia, and associated neonatal morbidity was examined in low- and mixed-risk populations. Performing a predefined literature search in Medline, Excerpta Medica database (EMBASE), the Cochrane library and ClinicalTrials.gov from inception to May 2020, 41 studies involving 112,034 patients were identified that offered third-trimester ultrasounds for the prediction of macrosomia as part of universal ultrasound screening or were done in low- and mixed-risk populations. The studies varied in quality, and there were only three studies blinding the ultrasound findings to the clinicians. The two most common ultrasound markers, the estimated fetal weight (EFW) and the abdominal circumference (AC), were identified to be predictive of the majority of macrosomic infants at birth (sensitivity > 50%) with high diagnostic performance (positive LRs between 7 and 10). However, only about 1 in 5 cases of shoulder dystocia (22% sensitivity) could be predicted with the EFW with low diagnostic performance (positive likelihood ratio of about 2). Data to analyze other markers of neonatal morbidity were insufficient .