Weir E, et al. - Via performing this mixed-methods study, researchers sought to compare the experiences of substance use between autistic and non-autistic adolescents and adults. Both quantitative (closed-ended questions) and qualitative (one open-ended question) online assessments were conducted and data were gathered as part of a larger study, the Autism and Physical Health Survey, in which an anonymised, online questionnaire was administered to autistic and non-autistic individuals aged 16–90 years. For the quantitative analyses, they included data from 2,386 participants (1,183 autistic and 1,203 non-autistic participants; 1571 female and 815 male participants) and in the qualitative analyses, they included data from 919 participants (429 autistic and 490 non-autistic participants; 569 female and 350 male participants). Per outcomes, likelihood to report engaging in substance misuse was less for autistic individuals relative to non-autistic individuals. In addition, autistic individuals report using drugs to self-medicate. Further, they recommend clinicians to have knowledge concerning vulnerability linked to substance use among autistic patients and to work cooperatively with patients to effectively manage autistic and comorbid symptoms.