Do NC, Vestgaard M, Ásbjörnsdóttir B, et al. - In this cohort study, no reduction in the prevalence of preeclampsia was observed in correlation with implementation of prophylactic aspirin for all pregnant women with diabetes compared with the previous risk-based prophylaxis.

• This prospective observational cohort study included 410 consecutive pregnant women with preexisting diabetes.

• Of these women, 207 women were included after implementation of prophylactic aspirin for all pregnant women with preexisting diabetes (all-cohort) and 203 women were included prior to the implementation, where aspirin prophylaxis was risk based and only prescribed to selected women (selected-cohort).

• 88% (all-cohort) vs 25% (selected-cohort) received aspirin at ∼10 gestational weeks.

• The two cohorts showed similar prevalence of preeclampsia, and this was also the case with stratification for diabetes type.

• The two cohorts had similar prevalence of preterm delivery < 37 weeks, preterm preeclampsia, and infants large and small for gestational age.