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Umbilical cord arterial and venous gases, ionogram, and glucose level for predicting neonatal morbidity at term

European Journal of Obstetrics & Gynecology and Reproductive Biology Aug 30, 2020

Vanspranghels R, Houfflin-Debarge V, Deken V, et al. - Researchers sought the best predictor of neonatal morbidity at term via investigating parameter of umbilical arterial cord gas analysis, pH, base deficit, lactate concentration, ionogram values, or glucose level index. In this 15-month retrospective cohort study of all nonanomalous, singleton, term births at a single center, receiver-operating characteristic curves were used for comparing the predictive ability of lactate concentration, base deficit, pH, ionogram values, and glucose level for global and neurological composite morbidity. Among 5,161 included newborns: 52 (1.01 %) had global composite morbidity, and 17 had (0.33 %) neurological composite morbidity. Outcomes support acid–base status analysis to be the best objective indicator for predicting neonatal morbidity; this can be determined using pH, lactate, or base deficit. For predicting global composite morbidity, optimal cutoff values were arterial pH 7.144, venous pH 7.236, and arterial lactate concentration 6.5 mmol/L. For this purpose, they identified no utility of Ionogram cord blood composition and glucose level.

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