Peterson C, et al. - Among patients discharged from inpatient stays for opioid overdose in the United States, researchers assessed 90-day readmissions. The national estimated proportion of patients with opioid overdose stays, with all-cause readmissions within ≤ 90 days, were identified by survey-weighted analysis of hospital stays in the 2016 Healthcare Cost and Utilization Project National Readmissions Database, which was conducted in 2018. Male, older age, drug use disorder, chronic pulmonary disease, psychoses, Medicare or Medicaid primary payer, and discharge against medical advice were all factors significantly related to both opioid overdose and non-opioid overdose readmissions. The investigators reported ≤ 90 days all-cause readmissions in a quarter of opioid overdose patients, although readmission due to opioid overdose was uncommon. Substance use disorder and comorbid physical and mental health conditions need to be addressed in effective strategies to attenuate readmissions.