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Typical and atypical carcinoid tumors of the lung: A clinicopathological correlation of 783 cases with emphasis on histological features

Human Pathology Apr 06, 2020

Moran CA, Lindholm KE, Brunnström H, et al. - Researchers described 783 surgical resections of typical and atypical carcinoid tumors of the lung distinguished in the pathology files of 20 different pathology departments. This study critically examined all cases for clinical and pathological features and further correlated with clinical outcomes. They obtained long-term follow-up in all the individuals and statistically examined to ascertain significance of the different parameters evaluated. Of the histopathological features analyzed, they distinguished the presence of mitotic activity of 4 mitoses or more per 2 mm2, necrosis, lymphatic invasion, and lymph node metastasis as statistically significant. The data recognize that the separation of low- and intermediate-grade neuroendocrine neoplasms of the lung necessary to be readjusted in terms of mitotic count as the risk of overgrading these neoplasms exceeds 10% under the current criteria. This study further demonstrate that tumor size is an important feature to be recognized in the evaluation of these neoplasms and together with the histological grade of the tumor offers important features that can be associated with clinical outcomes.

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