Wakamatsu T, Iwasaki Y, Yamamoto S, et al. - The present study was undertaken to evaluate the effect of type 1 angiotensin II receptor blockade (AT‐1RB) on preventing chronic kidney disease (CKD)‐related fragility fractures and elucidate its pharmacological mechanisms. There was an association between AT‐1RB and a lower risk of hospitalization due to fractures in 3,276 patients undergoing maintenance hemodialysis. This study's findings demonstrate that angiotensin II‐dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation. It was indicated that AT‐1RB contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD, possibly by oxidative stress.