Meador KJ, Cohen MJ, Loring DW, et al. - According to this multicenter cohort study, at 2 years of age, there was no difference in the outcomes of children of women with epilepsy (WWE) taking antiseizure medications (ASMs) and children of healthy women.

• The Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) assessments were carried out on 292 WWE children (median age, 2.1 [range, 1.9-2.5] years; 155 female [53.1%] and 137 male [46.9%]) and 90 healthy women children (median age, 2.1 [range, 2.0-2.4] years; 43 female [47.8%] and 47 male [52.2%]).

• On the primary outcome of language domain, no differences were found between groups.

• None of the other 4 BSID-III domains were different between WWE children and healthy women.

• The majority of WWE were on lamotrigine and/or levetiracetam.

• Exposure to ASMs in WWE children had no correlation with the language domain.

• Secondary analyses, on the other hand, showed that higher maximum observed ASM levels in the third trimester were associated with lower BSID-III scores in the motor domain, and higher maximum ASM doses in the third trimester were associated with lower scores in the general adaptive domain.