Li J, Zhong G, Wang K, et al. - Since no clear predictive indicators are currently available to determine if a patient with breast cancer can choose breast-conserving surgery, researchers herein employed cone-beam breast computed tomography (CBBCT) to retrospectively record the tumor-to-gland volume ratio and tumor-to-breast volume ratio in breast cancer patients. They assessed the correlation between the surgical methods and ratios in breast cancer cases. Participants were 100 patients receiving breast-conserving surgery (study group) as well as 100 patients receiving mastectomy (control group). Patients had CBBCT examination prior to surgery. Statistical difference was evident in tumor volume and the ratios of the two groups, while not in mammary gland and breast volume. In the study group and control group, the average tumor-to-gland volume ratio was 4.32% and 10.74%, respectively, and the average tumor-to-breast volume ratio was 0.74% and 1.36%, respectively. Overall, findings revealed that CBBCT-detected tumor-to-gland volume ratio and tumor-to-breast volume ratio were correlated with the choice of surgical methods (breast-conserving surgery or mastectomy) for breast cancer cases. This can serve as a likely predictor of breast-conserving surgery to assist surgeons.