Boakye EA, et al. - Researchers sought to characterize the incidence, most common tumor sites, and trends in burden of second primary malignancies (SPM) among survivors in this population-based study of patients diagnosed between 2000 and 2014 with a primary malignancy in the top 10 smoking-related cancer sites from Surveillance, Epidemiology, and End Results data. They identified a cohort of 1,608,607 patients; SPM developed in 119,980 (7.5%) of them. The highest risk of developing a SPM was in survivors of head and neck cancer; the highest excess burden was seen in urinary bladder cancer. The increase in the burden of SPM from smoking-related cancers over the last decade is significant, so clinicians should be aware of long-term smoking-related cancer risks among these patients as part of their survivorship care plans.