Patel K, Karalius B, Powis K, et al. - In view of small studies inscribing poor postpartum outcomes among young women living with perinatal HIV infection who are now aging into adulthood and becoming pregnant, researchers sought to determine the women in this population at risk of poor postpartum virological control. From the Pediatric HIV/AIDS Cohort Study-AMP Up protocol, a prospective study of young adults living with perinatal HIV from 14 sites in the USA, they used data on pregnancy history for women living with perinatal HIV infection. Three hundred twenty-three women were enrolled from April 15, 2014, to Oct 1, 2017; of these, 234 had perinatal HIV infection and reported age at sexual debut and history of heterosexual vaginal intercourse. In these women, 172 pregnancies were recorded; of these, 147 (85%, 104 livebirths and 43 spontaneous or elective abortions) were suitable for postpregnancy viral load trajectory analyses (ie, had at least two viral loads in the year after the end of pregnancy). Outcomes suggest that women living with perinatal HIV infection exhibit a high risk of postpartum viremia despite achieving success in viral load suppression during pregnancy. In this population, postpartum adherence interventions may most likely benefit women who were of younger age at conception, had preconception viremia, and preconception immune suppression.