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Trends in obstetric management of extreme preterm birth at 23 to 27 weeks’ gestation in a tertiary obstetric unit: A 10-year retrospective review

European Journal of Obstetrics & Gynecology and Reproductive Biology Aug 29, 2020

Garry N, Farooq I, Milne S, et al. - Researchers conducted a 10-year retrospective analysis including all women who delivered between 23 + 0 and 26 + 6 weeks gestation in a tertiary obstetric unit from January 1, 2007 to December 31, 2017 inclusive in order to evaluate maternal and perinatal outcomes in these deliveries. Inclusion of 340 women and 402 infants was performed. Following were the leading indications for delivery: preterm premature ruptured membranes (PPROM) (28.2 %), 8.5 % (29/340) severe preeclampsia (PET) and 5.6 % (19/340) delivered for suspected placental abruption. Of all infants (N = 402), stillbirth was reported for 18.9 % (76 /402). Admission to the Neonatal Intensive Care Unit (NICU) was reported in 300 infants. The overall perinatal mortality rate (PNMR) was 328.4/1000 and a further late neonatal mortality of 47.3/1000 births. Pregnant women delivering at extreme preterm gestations are noted to be at risk of maternal morbidity. Rates of serious morbidity and mortality were higher among their infants, with all survivors in this cohort affected by neonatal morbidity. Evidence based information on perceived outcomes, ideally individualized to the mother and pregnancy in question, is needed for informed decision-making by providers and parents. This retrospective cohort study yields information that can be employed to counsel women and their families on potential morbidity and mortality and to manage expectations.

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