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Trends in fractures in patients with spondyloarthritis: A nationwide population-based study (TREND-EspA study)

Osteoporosis International Aug 05, 2021

Mazzucchelli R, Almodovar R, Dieguez-Costa E, et al. - The study found only an increase of axial fractures, more specifically vertebral fractures, in spondyloarthritis (SpA). In both cohorts, the trend in incidence is similar.

  • The age and gender-adjusted rates per 100,000 inhabitants/year of total fracture and different types of fracture were 45.72 any fractures, 17.64 axial, and 28.02 peripheral; 29.42 osteoporotic (12.67 vertebra, 12.29 hip, 1.50 pelvis, 1.82 humerus and 2.09 radius) in the SpA cohort.

  • There were 65.79 any, 12.08 axial, 51.52 peripheral; 31.17 osteoporotic (4.94 vertebra, 16.15 hip, 2.29 pelvis, 3.64 humerus, 5.38 radius) in the non-SpA cohort.

  • The trend in incidence rate for total fracture and different types of fracture increased similarly for both cohorts between 1999 and 2015.

  • An increase of axial fractures was found (AOR 1.444; 95%CI 1.297–1.609), and specifically of vertebral fractures (AOR 2.440; 95%CI 2.097–2.839) in the SpA cohort. It has been reported that other types of fractures did not increase.

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