Desai R, et al. - In this retrospective cohort study, researchers used National Inpatient Sample databases (2010–2014) to evaluate the frequency of atrial fibrillation as well as its influence on results of sepsis-related hospitalizations. With the primary diagnosis of sepsis, 5,808,166 hospitalizations were included; 19.4% (1,126,433) were related to atrial fibrillation. Older white patients with an extended length of stay and higher hospitalization costs constituted the sepsis-atrial fibrillation cohort vs the nonatrial fibrillation cohort. In the atrial fibrillation-sepsis cohort, African American race, female sex, advanced age, and the presence of medical comorbidities were identified as the greatest predictors of death. In this study, poor prognosis and increased death were indicated by the presence of atrial fibrillation among sepsis-related hospitalizations. Throughout the study duration, although the observed trends in sepsis and sepsis-atrial fibrillation–related hospitalizations increased, a progressive decline in the rate and odds of mortality was evident.