Walter N, Popp D, Freigang V, et al. - For improvement of infection prevention and of clinical outcomes in orthopedics and trauma surgery setting, a suggested strategy is the usage of antimicrobial-coated implants. Researchers herein examined outcomes in a patient cohort with high risk of infection/reinfection and treatment failure after surgical treatment using a gentamicin-coated nail. They focused on treatment success in terms of bone consolidation, absence of infection, and patient-reported quality of life. Retrospective review of a total of 13 patients with open tibia fractures (n = 4), non-unions (n = 2), and fracture-related infection (n = 7) treated with a gentamicin-coated intramedullary nail (ETN Protect) was done. Eleven of the 13 patients (84.6%) showed bone consolidation without any additional surgical intervention at a mean follow-up of 2.8 years, whereas two patients necessitated revision surgery due to infection and removal of the implant. Findings suggest that in open fractures and revision surgery, it seems reasonable to use a gentamicin-coated intramedullary nail for aseptic non-union or established fracture-related infection to avoid infection complications and to achieve bony union. Although gentamicin-treated implant was linked with successful treatment of challenging cases, there was significantly reduced quality of life after treatment highlighting the necessity for further efforts to improve surgical treatment strategies and psychological support.