Masuda M, et al. - In myasthenia gravis (MG) patients, researchers examined how treatment with cholinesterase inhibitors (ChEIs) and calcineurin inhibitors (CNIs) impacts the occurrence of cramps via evaluating the frequency and duration of cramps and serum electrolytes in 81 subjects with MG. These findings suggested that treatment with a high dose of ChEI (≥180 mg/d) and CNI accelerated the probability of cramps and decreased the quality of life (QOL) in MG patients. As compared to patients not treated with CNI, the serum magnesium concentrations were lower in those treated with CNI. In patients treated with ChEIs in addition to CNI vs patients who were treated with a low dose of ChEIs without concomitant CNI treatment, there was a significantly higher probability of cramps.