van Roeden SE, et al. - Researchers designed this work to assess the effectivity of first line treatment for chronic Q fever, tetracyclines (TET) plus hydroxychloroquine (HCQ), and potential alternatives. Findings suggested that treatment of chronic Q fever with TET plus quinolones (QNL) was a safe alternative for TET plus HCQ, for example if TET plus HCQ cannot be tolerated due to side effects. In this work, treatment with TET plus QNL plus HCQ seemed not superior to treatment with TET plus HCQ, although this may be caused by confounding by indication. They recommended avoiding treatment with TET or QNL monotherapy. Because of subjective insufficient clinical response, switches were frequently observed.