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Treatment and long-term clinical outcomes of incidental pulmonary embolism in patients with cancer: An international prospective cohort study

Journal of Clinical Oncology Jul 10, 2019

Kraaijpoel N, et al. - Researchers conducted an international, prospective, observational cohort study of 695 patients with cancer to investigate the current treatment strategies and the long-term clinical outcomes of incidentally detected pulmonary embolism in these cases. Colorectal (21%) and lung cancer (15%) were the most frequent cancer types. Among 675 patients (97%), anticoagulant therapy was initiated; low-molecular-weight heparin was used in treating 600 (89%) of these patients. They noted recurrent venous thromboembolism in 41 patients (12-month cumulative incidence, 6.0%), major bleeding in 39 patients (12-month cumulative incidence, 5.7%), and reports of the death for 283 patients (12-month cumulative incidence, 43%). Patients with cancer with incidental pulmonary embolism displayed a significant risk of recurrent venous thromboembolism despite receiving anticoagulant treatment. Patients with subsegmental pulmonary embolism had recurrent venous thromboembolism risk comparable to that of patients with more proximal clots.
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