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Treatment abandonment in children with cancer: Does a sex difference exist? A systematic review and meta‐analysis of evidence from low‐ and middle‐income countries

International Journal of Cancer Sep 27, 2020

Palagyi A, Balane C, Shanthosh J, et al. - Researchers conducted this systematic review and meta‐analyses to determine sex‐disparities in treatment abandonment in children with cancer in low‐ and middle‐income countries (LMICs) and identify the features of children and their families most disadvantaged by such abandonment. Sex‐disaggregated data on treatment abandonment were collated from the available literature and a random‐effects meta‐analysis was carried out to compare the rates in girls with those in boys. Participants in the study were 10,754 children. In the included studies in LMICs, a high rate of treatment abandonment (30%) was found overall for children with cancer, although this was variable and context specific. No evidence of gender bias in childhood cancer treatment abandonment rates across LMICs was discovered. Given that the risk factors for abandonment are context specific, in‐depth country‐level analyses can provide further insights into the role of a gender of a child in treatment abandonment decisions.

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