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Treat to target and prevention of subclinical atherosclerosis in psoriatic arthritis — Which target should we choose?

Rheumatology Mar 01, 2020

Cheng IT, Li EK, Wong PC, et al. - In this study, the vascular effects of achieving different treatment targets in PsA patients were compared. Researchers included a total of 101 consecutive psoriatic arthritis (PsA) individuals without overt cardiovascular disease. They annually measured high-resolution carotid ultrasound and arterial stiffness markers. Low disease activity (LDA) was determined as MDA, DAPSA ≤ 14 or PASDAS ≤ 3.2. They defined sustained disease control as achieving these targets at each visit from month 12 until month 24. It is indicated that achieving sMDA/sDASPAS-LDA, but not sDAPSA-LDA was correlated with a protective impact in subclinical atherosclerosis and arterial stiffness progression. In PsA, a multidimensional domain of disease control might be better in reducing cardiovascular risk.
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