Brauer R, et al. – Via analysis of UK population-based electronic health records, researchers evaluated the correlation between trazodone use and the risk of developing dementia in clinical practice. Between January 2000 and January 2017, patients from The Health Improvement Network (THIN) aged ≥ 50 years who received ≥ 2 consecutive prescriptions for an antidepressant were evaluated. Using a Cox regression model with 1:5 propensity score matching, the risk of dementia was compared among patients prescribed trazodone with patients who had similar baseline characteristics but were prescribed other antidepressants. Eligible patients prescribed trazodone (n=4,716; 59.2% female) were older and had a greater likelihood of developing cerebrovascular disease and using anxiolytic or antipsychotic drugs vs those prescribed other antidepressants (n=420,280; 59.7% female). No association was found between trazodone use and a reduced risk of dementia vs other antidepressants. According to findings, a reduced risk of dementia was not related to the clinical use of trazodone.