Brauer R, et al. - This electronic health records study assessed the association between trazodone use and the risk of developing dementia in clinical practice. Using the Health Improvement Network (THIN), an archive of anonymised medical and prescribing records from primary care practices in the United Kingdom, researchers assessed patients aged ≥50 years who received at least two consecutive prescriptions for an antidepressant between January 2000 and January 2017. The risk of dementia among 4,716 users of trazodone was compared to the risk of 420,280 users of other antidepressants with similar baseline characteristics. Outcomes of this large, UK population-based study suggest no association between trazodone use and a reduced risk of dementia compared with other antidepressants. They observed an early onset of dementia among trazodone users, which seemed to contradict the suggestions from animal studies that trazodone could stop or delay the onset of dementia. Although patients taking trazodone had a higher incidence of dementia than that observed among patients taking other antidepressants, the risk differences were closer to zero with increasing duration of treatment. This suggests that people in the prodromal stage of dementia might be more likely to be prescribed trazodone.