Ritchie K, Carrière I, Gregory S, et al. - In the present study, the researchers sought to explore the connections between childhood trauma, depression, adult cognitive functioning and risk of dementia. They used linear and logistic models to evaluate correlations between childhood trauma, depression, dementia risk, cognitive test scores and hippocampal volume using data from 378 patients aged 40–59 years in the PREVENT Dementia Study. Depression and reduced hippocampal volume, but not current cognitive function or dementia risk, were linked with childhood trauma, though poorer cognitive performance was mediated by depression rather than structural brain differences. Via multiple pathways, depressive symptomatology can be correlated with dementia risk and subtypes of depressive symptomatology should be considered when evaluating its relationship to dementia.