Darmoch F, et al. - Among subjects with cryptogenic stroke, researchers investigated the safety and effectiveness of the patent foramen ovale (PFO) closure compared with medical therapy. The mean age of patients was mean age 45 years, with a mean follow-up of 2.9 years. In contrast with the medical therapy, a statistically prominent risk reduction in risk of recurrent stroke was achieved in the PFO closure group, as revealed via a random effects model. It was noted that the I² heterogeneity test was 48%. Hence, the inference drawn was that PFO closure served as a safe and effective intervention for the prevention of stroke recurrence compared with medical therapy in patients with cryptogenic stroke.