Spitler CA, Row ER, Gardner WE II, et al. - Via a prospective, randomized controlled trial, the researchers evaluated the safety and efficiency of tranexamic acid (TXA) use in fractures of the pelvic ring, acetabulum, and proximal femur. Forty-seven and 46 patients were randomized to the study group and the control group, respectively. In the control group, total blood loss (TBL) was significantly greater. Between the TXA and control groups, the total transfusion rates were not significantly different. No notable variations between the TXA and control groups in inpatient venous thromboembolic events (VTE) were found. Hence, in high-energy fractures of the pelvis, acetabulum, and femur, the use of TXA significantly reduced calculated TBL, however, it did not reduce overall transfusion rates. TXA did not raise the rate of VTE. Further study is needed prior to making broad recommendations for the use of TXA in these fractures.