Eljaszewicz A, Ruchti F, Radzikowska U, et al. - Researchers focused on systemic innate immune cell repertoire in the course of allergen-specific immunotherapy (AIT), in this comprehensive, longitudinal analysis. In allergic patients, standard preseasonal subcutaneous AIT with allergoids to birch and/or grass was administered. The monitoring of healthy controls was performed without any intervention. A durable reduction of ILC ( Innate Lymphoid Cells)2 and rise of ILC1 following AIT were seen with dynamic alterations in their composition. Experts noted a rise in intermediate monocytes, in parallel to the decrease of non-classical monocytes during the first year post-AIT. Findings demonstrated that AIT not only provoked alterations in the composition and heterogeneity of circulating innate immune cells but also brought them to the level noted in healthy people. Experts suggested that monitoring of ILC, monocytes, and dendritic cells during AIT might represent a novel biomarker strategy.