Hirano K, Tanaka H, Kato K, et al. - Through retrospectively reviewing the records of patients who visited the Cornea Service at Fujita Health University Bantane Hospital and were treated for infectious keratitis from April 2016 to March 2020, researchers sought to review the clinical characteristics and visual outcomes of patients with severe corneal ulcers who have been treated with topical corticosteroids and examine the background of the prescription of topical corticosteroids. Out of the 200 eyes of 197 patients with infectious keratitis, 14 eyes of 14 patients were treated with topical corticosteroids prior to culture-proven diagnosis. The use of topical corticosteroids for keratitis that does not respond to empirical antibiotic therapy is dangerous because these topical antibiotic-resistant cases are likely to include Acanthamoeba keratitis or fungal keratitis. When prescribing topical corticosteroids for the treatment of suspected infectious keratitis, microbiological evidence, as well as the differential diagnosis of herpetic stromal keratitis, is needed.