Gill PK, et al. - In this pilot study, researchers for the first time examined the timing of infections following intravenous immunoglobulin (IVIg) infusion in individuals with common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA), presuming that the rate of infection would be higher during the time period when serum IgG approaches its trough ie, during the third and fourth week after infusion. They performed a mean follow up of 11.3 months in participants ie, 23 patients with a diagnosis of either CVID (n = 22), or XLA (n = 1) who received IVIg infusion. The mean number of days to infection after IVIg infusion, the primary endpoint, was 17.0 days. The most commonly documented infections were sinusitis and upper respiratory tract infections. No statistically significant difference was observed in the rates of infection when considering the weeks post-infusion.