Prada C, Marcano-Fernández FA, Schemitsch EH, et al. - The incidence or prevalence of fracture-related surgical site infections (SSIs) after open fractures has been studied widely. Researchers here addressed the gaps remaining concerning their timing and management outcomes using data from the Fluid Lavage of Open Wounds trial. There were 2,445 participants in the Fluid Lavage of Open Wounds trial; of these participants, 325 (13.3%) had an SSI. Significantly earlier diagnosis of superficial SSIs was observed [26.5 days, interquartile range (IQR) 12–48] than deep or organ/space SSIs (53 days, IQR 15–119). Among 325 patients with SSIs, 174 and 151 were treated operatively and nonoperatively, respectively. In contradistinction to the Centers for Disease Control and Prevention guidelines, findings from this study suggest that superficial SSIs were diagnosed at 1 month after an open fracture and deep/organ/space SSIs at 2 months. This information seems to be valuable for earlier detection of infection. Furthermore, the knowledge that nearly 50% of the SSIs in this study necessitated a reoperation and 3 months at a minimum to resolve will aid orthopedic surgeons when counseling their patients.