Wang FF, et al. - Researchers gauged the T-cell immunoglobulin and ITIM domain (TIGIT) expression and its impacts on CD4+ T-cell function in psoriasis. Findings suggested a probable contribution of downregulation of TIGIT on CD4+ T cells to the pathogenesis of psoriasis, and a potential therapeutic target could be the activation of the TIGIT signalling pathway. Significantly lower IGIT expression on CD4+ T cells and levels of mRNA were seen in patients with psoriasis vulgaris (PV) vs healthy controls (HCs). A negative association of TIGIT expression with Psoriasis Area and Severity Index was seen.