Han Q, et al. - In 146 biopsy-confirmed diabetic nephropathy (DN) patients, researchers examined the link between thyroid hormones and clinicopathologic changes via analysis of clinical and pathological data. Patients were classified into four groups: euthyroid group, high-thyroid stimulating hormone (TSH) group (SCH), low-free triiodothyronine (FT3) group (with normal levels of TSH and FT4), and high-TSH + low-FT3 group (with normal levels of FT4). The investigators analyzed the risk of abnormal thyroid hormone levels on DN via logistic regression with multivariable adjustments for other risk factors. The euthyroid group and high-TSH group had significantly differed overt proteinuria (>5 g/24 hours) and severity of glomerular lesions. Moreover, a significant difference was observed between the euthyroid group and low-FT3 group in terms of levels of estimated glomerular filtration rate, serum creatinine, and severity of glomerular lesions. The most severe renal clinicopathologic changes were seen among patients with TSH levels of 4.54–5.67 mU/L. Overall, more severe proteinuria, renal insufficiency, and glomerular lesions were observed in DN patients with high-TSH and/or low-FT3. Findings were suggestive of a potential renoprotective effect of regulating thyroid hormones.