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Thyroid function in early pregnancy, child IQ, and autistic traits: A meta-analysis of individual participant data

Journal of Clinical Endocrinology & Metabolism Aug 12, 2018

Levie D, et al. - In countries with a different iodine status, researchers evaluated the relationship of maternal thyroid function during early pregnancy with child neurodevelopment. Main outcomes were child’s nonverbal IQ at 5 to 8 years of age, verbal IQ at 1.5 to 8 years of age, and autistic traits within the clinical range at 5 to 8 years of age. A link between hypothyroxinemia and a greater risk of autistic traits was suggested, but no independent link was seen with TSH. The findings from the present study suggested that, consistently across the cohorts, low maternal free T4 (FT4) was correlated with a lower IQ. Regardless of the type of immunoassay, FT4 appears as a reliable marker of fetal thyroid state in early pregnancy.

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