Three‐year observation of children 12 to 35 months old with untreated intermittent exotropia
Ophthalmic and Physiological Optics Mar 28, 2020
Cotter SA, Mohney BG, Chandler DL, et al. - In the present study, the researchers sought to characterize the clinical course of untreated intermittent exotropia (IXT) in children 12–35 months of age followed for 3 years. The sample consisted of 97 children (12–35 months of age) with previously untreated IXT who had been randomly assigned to the observation arm of a randomised trial of short‐term occlusion vs observation. Participants in the study were observed unless deterioration criteria were met at a follow‐up visit occurring at 3 months, 6 months, and 6‐month intervals thereafter for 3 years. Data reported that the cumulative probability of deterioration by 3 years was 28% and the cumulative probability of motor deterioration by 3 years was 10%. Given the modest rate of motor deterioration over three years, watchful waiting in 12‐ to 35‐month‐old children with IXT could be a rational management strategy. To validate this recommendation, immediate treatment vs observation will require a long‐term randomised trial followed by deferred treatment if necessary.
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