Levy RM, Mekhail N, Kramer J, et al. - In the ACCURATE randomized, controlled trial, outcomes of dorsal root ganglion (DRG) stimulation were compared with those of tonic spinal cord stimulation (SCS) among 152 individuals with chronic lower extremity pain due to complex regional pain syndrome (CRPS) type I or II. Researchers here designed an ACCURATE substudy to assess the occurrence of therapy habituation with DRG stimulation as compared with SCS through 12-months. They evaluated percentage pain relief (PPR) and responder rates at follow-up visits (end-of-trial, 1, 3, 6, 9, 12-months postpermanent implant) for all individuals that completed trial stimulation (DRG: N = 73, SCS: N = 72) via performing a modified intention-to-treat analysis. After permanent DRG system implantation, PPR did not differ significantly between any of the time points (range = 69.3–73.9%). For the SCS group, significantly less PPR was reported at 9-months (58.3%) and 12-months (57.9%) than at 1-month (66.9%). Further, they observed a decrease in the responder rate for the SCS group from 1-month (68.1%) to 12-months (61.1%). Only the CRPS-I population exhibited diminishing pain relief with SCS following stratifying by diagnosis. More stable pain relief was observed with DRG stimulation through 12-months, while tonic SCS illustrated therapy habituation at 9- and 12-months.