Helito CP, Sobrado MF, Giglio PN, et al. - This research was attempted to correlate the complications of patients undergoing total knee arthroplasty (TKA) who applied a portable negative-pressure wound therapy (NPWT) device in the immediate postoperative period with those of a control group. Researchers assessed a sum of 296 patients. Individuals were categorized into two groups: those who applied NPWT for seven days in the postoperative period (Group 1 – prospective evaluated) and those who used conventional dressings (Group 2 – historical control group). They assessed epidemiological data, comorbidities, local parameters related to the surgical wound, and complications. After TKA, the number of complications related to the wound is high; nevertheless, most of them are minor and have no effect on the treatment and clinical evolution of individuals. The use of NPWT reduced the number of surgical wound complications, particularly hyperaemia, dehiscence and necrosis, and decreased the requirement for reintervention.