Wei H, Hongwei L, Ying S, et al. - In acute coronary syndrome (ACS) patients who received percutaneous coronary intervention (PCI), U-shape associations between pulse pressure (PP) level and all-cause and cardiac mortalities were identified. The U-shape links vanished in the left ventricular ejection fraction (LVEF) > 0.5 cohort. The reference PP level was 55 mm Hg.

• A total of 5055 ACS patients who received PCI were analyzed (median follow-up was 24 months) for the link between pulse pressure and long-term mortality.

• A significant elevation in the risk of death was noted, when PP was used as categorical variable, in the high PP group (≥61 mm Hg) vs the intermediate PP group (50–60 mm Hg) in the both cohorts (whole cohort and the LVEF > = 0.5 cohort).

• When PP was used as a continuous variable, there was a U-shape association between PP and mortalities in the entire cohort, with reference PP level of 55 mm Hg.

• However, this U-shape link disappeared in the LVEF > 0.5 cohort.

• Similar findings were seen in the myocardial infarction subgroup.