Vanner EA, Sun CQ, McSoley MJ, et al. - Researchers sought to evaluate the feasibility of replicating a randomized control trial (RCT) with a cohort of eyes, from IRIS Registry data, analogous to the Tube Versus Trabeculectomy (TVT) RCT cohort and compare characteristics and follow-up. A cohort of IRIS Registry eyes (2013-2017) was reported that obtained either glaucoma drainage implant (tube) or trabeculectomy following prior trabeculectomy and/or cataract extraction. The IRIS Registry cohort involved 419 eyes: 183 (43.7%) trabeculectomy; 236 (56.3%) tube. The TVT IRIS Registry cohort had some substantial differences in the baseline treatment group, although none in the TVT RCT cohort had been identified. The TVT IRIS Registry cohort follow-up was inferior to that of the TVT RCT. Some of the data needed to refine the collection of eyes for the cohort were not available in the IRIS Registry.