Park HM, Lee HS, Lee YJ, et al. - Type 2 diabetes (T2D) can be better predicted by the triglyceride–glucose (TyG) index vs homeostatic model assessment of insulin resistance (HOMA-IR), thus, the TyG index could afford a more beneficial tool for early detection and prevention of T2D.

• Data were obtained from 9,730 adults aged 40–69 years at baseline and 7,783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey.

• Average follow-up span was 9.0 years.

• The TyG index was superior to HOMA-IR in predicting the prevalence of T2D (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001).

• For incident T2D, the TyG index yielded a significantly higher area under the time-dependent receiver operating characteristic curve [0.640 (0.628–0.652)] than HOMA-IR [0.531 (0.521–0.541)].