Bullen AL, et al. - Researchers examined the associations of measured urine markers of tubular function and injury (neutrophil gelatinase-associated lipocalin [NGAL], kidney injury molecule-1, interleukin-18 [IL-18], monocyte chemoattractant protein-1, and chitinase-3-like protein [YKL-40]) at baseline, with subsequent acute kidney injury [AKI] risk among Systolic Blood Pressure Intervention Trial participants with an estimated glomerular filtration rate (eGFR) under 60 ml/min/1.73m². Findings revealed the association of lower uromodulin and higher α−1 microglobulin [α−1m] with subsequent AKI, independent of eGFR and albuminuria. No link of any of the five injury markers with eventual AKI was evident. They found longitudinal increments in urine NGAL, IL-18, and YKL-40 in those with AKI vs only one marker of tubule function (α1-m), among 59 patients with intervening AKI in a random subset of 947 patients with repeated measurements.