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The spectrum of polypoidal choroidal vasculopathy in Caucasians: Clinical characteristics and proposal of a classification

Graefe's Archive for Clinical and Experimental Ophthalmology Aug 21, 2020

van Dijk EHC, Mohabati D, Veselinovic S, et al. - A retrospective review of medical charts was conducted to describe the clinical features and outcome of polypoidal choroidal vasculopathy (PCV), also known as aneurysmal type 1 (sub-retinal pigment epithelium (RPE)) neovascularization, in Caucasian patients. It was a single-centre study in 66 Caucasian individuals with a diagnosis of PCV based on optical coherence tomography scan and indocyanine green angiography. The sample consisted of 66 patients (74 eyes) with PCV, with a mean age at onset of 73 years and a female preponderance of 66%. For Caucasian patients, a spectrum of PCV (aneurysmal type 1/sub-RPE neovascularization) can be observed. In Caucasians, PCV correlated with a drusenoidal neovascular AMD phenotype is phenotypically and presumably pathophysiologically more related to neovascular AMD (PCV-AMD: type A PCV). This may not be the case, however, in patients with PCV with non-polypoidal type 1 choroidal neovascularization or BVN and no signs of drusenoidal AMD (PCV-BVN: type B PCV), and in patients with idiopathic PCV without associated drusen or BVN (iPCV; type C PCV). There is a thin choroid in most cases, even though drusen is absent. A moderate anatomical recovery was observed after treatment for the entire patient group.

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