Kulkarni T, et al. - Since an association of cellular senescence with the pathogenesis of idiopathic pulmonary fibrosis (IPF) has been suggested and in view of this, researchers assessed plasma CCN1 (a matricellular protein) levels as well as its potential role in clinical results among patients with IPF, given pre-clinical models have demonstrated cellular senescence induced by CCN1 as well as its contribution to lung fibrosis. Experts examined 88 IPF patients at the University of Alabama at Birmingham. Via ELISA, the levels of CCN1 in plasma specimens were analyzed. They collected measurements of forced vital capacity (FVC) and diffusion capacity for carbon monoxide (D_LCO), expressed as percentages of predicted values (%FVC and %D_LCO, respectively). Transplant-free survival duration was considered as the primary outcome measure. Lower transplant-free survival was reported in relation to high-CCN1 levels, independent of %FVC and %D_LCO, vs patients with low plasma CCN1. In IPF, survival may be predicted by plasma levels of CCN1. As the possible role of CCN1 in cellular senescence and pathobiology of IPF is given, further inquiry into the predictive value of CCN1 in disease progression among IPF patients is warranted.