Egeberg A, et al. - Given Th17 cells subset now known as the fundamental cells in the key controlling pathway implicated in the pathogenesis of psoriasis, and psoriasis has been found as a risk factor for cardiovascular and metabolic disease, therefore, researchers reviewed the involvement of the interleukin‐23 (IL‐23)/Th17 axis in the shared psoriasis‐cardiometabolic pathogenic mechanisms, and addressed this topic taking into account the existing preclinical as well as clinical evidence, including that from comorbid psoriasis patients. A seemingly crucial role of IL‐23/IL‐17 upregulation in both myocardial damage and stroke has been observed, and for both associated conditions, interesting reports on deleterious effect neutralization following administration of related anti‐bodies are existing. Raised levels of IL‐23/IL‐17 have been detected in diabetic patients, and a synergistic role of IL‐23/IL‐17 in β‐cells damage is supported by available data. Reports have also shown signs of an expansion of Th17 subset in adipose tissue in obesity, and high levels of IL‐23 in obese patients. The predominance of IL‐23 and other associated pro‐inflammatory factors in non‐alcoholic fatty liver disease, closely associated with metabolic syndrome, as well as in other mentioned cardiometabolic disorders, has been shown to be involved in their pathogenesis.