Llorente-González S, Hernandez M, González-Zamora J, et al. - Researchers conducted the study for analyzing the impact of clinical factors on the development and progression of atrophy and fibrosis in patients with neovascular age-related macular degeneration (nAMD) receiving long-term treatment in the real world. An ambispective (retrospective and prospective) 36-month multicentre study, involving 359 nAMD patients from 17 Spanish hospitals treated according to the Spanish Vitreoretinal Society guidelines, was designed. One of two nAMD patients treated for 3 years had atrophy and/or fibrosis. Both, particularly fibrosis, cause vision loss. In routine clinical practice, subretinal fluid is associated with better visual outcomes and lower rates of atrophy and fibrosis, whereas intraretinal fluid is associated with worse visual outcomes and a higher risk of atrophy and, particularly, fibrosis.