Srisawat N, Kulvichit W, Tungsanga S, et al. - Given innate immunity represents a crucial host response to infection, but there is a lack of knowledge regarding the role of innate immunity as a prognostic biomarker in severe sepsis, therefore, researchers assessed the discriminatory features of these biomarkers on clinical results in this retrospective analysis of critically ill patients with severe sepsis. Overall 136 patients were enrolled in this study with a primary endpoint of 28 day-mortality. By determining neutrophil chemotaxis activity and CD-11b (cluster of differentiation 11b) expression, they evaluated neutrophil function. mHLA-DR expression and presepsin level were measured to assess monocyte function. Two groups of patients were defined: survivors (n = 63, 46.3%) and non-survivors (n = 73, 53.7%). Survivors exhibited significantly higher neutrophil chemotaxis activity. Only reduced neutrophil chemotaxis activity was found to be related to 28-day mortality. For the prediction of 28-day mortality, the highest AUC of 0.90 (0.84–0.96) was generated by combining neutrophil chemotaxis activity with mHLA-DR, CD-11b expression, presepsin, and SOFA score (sequential organ failure assessment). Overall, a promising new immunologic biomarker for predicting the clinical result in this patient population is seemed to be afforded by neutrophil chemotaxis activity.