Guo T, Qin Y, Gao X, et al. - In this retrospective analysis of 281 infertile couples, researchers focused on the impact of chromosomal polymorphism in men on spermatogenesis as well as the outcome of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)-ET. For this purpose, they evaluated fertilization rate, implantation rate, pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, early miscarriage rate and preterm rate. Significantly higher frequencies of severe oligozoospermia and azoospermia were observed in men with chromosomal polymorphism vs those without. Polymorphism-carrying men with severe oligozoospermia vs non-carriers with severe oligozoospermia had lower fertilization rate and clinical pregnancy rate, significantly. This is indicative of adverse influences of chromosomal polymorphism on spermatogenesis, negatively altering the outcome of IVF/ICSI-ET treatment. In infertile men, the most prevalent polymorphism was polymorphic variations on the Y chromosome, with the most frequent existence in patients with severe oligozoospermia.