Jordon LH, Gore RB, Rusk RA, et al. - By performing a clinical case series and literature review, researchers sought to determine the role of impulse oscillometry system (IOS) in the diagnosis and monitoring of asthma in patients in whom forced expiratory manoeuvres are contraindicated. They analyzed data from 12 patients suffering from inherited connective tissue disorders representing 32 clinical encounters. Among these, 11 encounters were for asthma diagnosis and 21 were for asthma monitoring. As revealed in the clinical case series, there was presence of abnormal IOS parameters in 5 of 6 patients with likely asthma (as ascertained by physician review and exhaled nitric oxide testing) vs 0 of 5 of those with unlikely asthma. In the monitoring group, treatment escalation (showing suboptimal control) resulted from 11 encounters, and 8 led to no alteration to treatment (good control). Findings indicate that IOS can be employed as an alternative tool to conventional pulmonary function testing to support the diagnosis as well as monitoring of asthma when forced expiratory manoeuvres are contraindicated.