Scarano A, Sbarbati A, Amore R, et al. - Researchers sought to conduct a clinical and histological evaluation of the impact of low-molecular-weight hyaluronic acid fragments mixed with amino acid (HAAM) on the rejuvenation of face skin treated with intradermal microinjections. Twenty women were studied, with a mean age of 45 ranging from 35 to 64, 8 of whom were in menopause and 12 of childbearing age. The current study's clinical results show that administering a dermal filler containing fragments of hyaluronic acid between 20 and 38 monomers and amino acid through dermis injection technique produces an esthetic improvement in the faces of the treated patients, while the histological evaluation reveals increased fibroblast activity with the production of type III reticular collagen and increased number of vessels and epidermis thickness. According to clinical and histological evaluation, subcutaneous HAAM infiltration has a significant impact on the dermis and clinical aspects of the face.