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The risk to future pregnancies of transfusing Rh(D)‐negative females of childbearing potential with Rh(D)‐positive red blood cells during trauma resuscitation is dependent on their age at transfusion

Vox Sanguinis Jan 31, 2021

Seheult JN, Stram MN, Pearce T, et al. - Researchers developed a risk assessment model for prognosticating the risk of hemolytic disease of the fetus and newborn (HDFN) in future pregnancies following the transfusion of Rh(D)‐positive red blood cell (RBC)‐containing products to females of childbearing potential (FCP), accounting for the age that the FCP is transfused in various countries. The following inputs were incorporated in the HDFN risk prediction model: risk of FCP death in trauma, Rh(D) alloimmunization rate following Rh(D)‐positive RBC transfusion, expected number of live births following resuscitation, probability of carrying an Rh(D)‐positive fetus, the probability of HDFN in an Rh(D)‐positive fetus carried by an alloimmunized mother. For each country, the risk predictions expressed similar characteristics that the overall risk of having a pregnancy affected by HDFN was greater if the FCP was younger when she was administered her Rh(D)‐positive transfusion than if she was older.

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