Baroncini D, Simone M, Iaffaldano P, et al. - Researchers undertook this retrospective, multicenter, observational study to assess how pediatric-onset multiple sclerosis (POMS) prognosis has changed over time in association with changes in therapeutic and managing standards. Data were obtained from the Italian MS Registry. A total of 3198 patients with POMS (mean age at onset, 15.2 years) were enrolled. Both for the Expanded Disability Status Scale score of 4.0 and 6.0, a gradual reduction in the cumulative risk of reaching disability milestones has been observed over time. In later diagnosis epochs, a greater number of POMS patients were managed with disease-modifying therapies, particularly high-potency drugs, that were administered earlier and for a longer duration. No significant change in demographic features as well as in clinical disease activity at onset was noted over time. Overall, persistent disability risk in POMS has been decreased by 50% to 70% in recent diagnosis epochs, and this may be attributable to improvement in therapeutic and managing standards.