Tapiainen V, Lavikainen P, Koponen M, et al. – Using a nationwide register-based cohort, researchers investigated the link between antipsychotic use and the risk of head injuries. The study sample consisted of Finnish community dwellers who received clinically confirmed Alzheimer disease (AD) diagnosis between 2005 and 2011. Using the Prescription Register, the researchers identified incident antipsychotic users who were then matched with nonusers by age, sex, and time since AD diagnosis (21,795 matched pairs). Individuals with previous head injury or a history of schizophrenia were eliminated. A higher risk of traumatic brain injuries (TBIs) was observed among quetiapine users vs risperidone users. Besides earlier recorded adverse events and effects, the possibility of increased risk of head injuries and TBIs consequent to antipsychotic use in individuals with AD was suggested by the findings of this study. Thus, the researchers suggested restricting their use to the most severe neuropsychiatric symptoms.